Abstract

ANTI-DIABETIC ACTIVITY OF METHANOLIC EXTRACT OF ANOGEISSUS LATIFOLIA WALL IN SWISS ALBINO RATS BY USING STREPTOZOTOCIN INDUCED DIABETIC MODEL

Shalini. K¹, Vijusha. M*, Rajani. A² , B.Rajesh and Hemamalini. K³

Abstract

The Anti-Diabetic activity of methanolic extract of Anogeissus latifolia Wall (combretaceae) was investigated in streptozotocin induced diabetic albino rats and extract was compared with the standard using glibenclamide. Anogeissus latifolia widely used in traditional system of medicine to treat diabetes in india. The Methanolic extract 300mg/kg of leaves were taken to evaluate the antidiabetic activity against normal and streptozotocin induced diabetic mice. Oral administration of the extracts for 21 days resulted in a significant reduction in blood glucose level. The extracts on serum cholesterol, triglycerides, creatinine, urea, alkaline phosphatise levels were decreased. Significantly by all the extracts and glibenclamide but HDL levels and total protein were found to be increased after treatments. Thus this study shows that anogeissus latifolia has antidiabetic action and the extracts should further be subjected to bioactivity guided drug discovery to isolate a lead compound responsible for this activity.

Keywords: Anogeissus latifolia, Anti-Diabetic activity, streptozotocin, Acute oral toxicity.