Abstract

A STUDY OF THE EFFECT OF HYOSCINE BUTYL BROMIDE ON THE DURATION OF LABOUR

Sreelatha S, Vedavathy Nayak*, Gayathri C , Renuka Ramaiah

Abstract

Objective: The purpose of this study was to assess whether hyoscine butyl bromide is effective in improving cervical effacement and dilatation, thus reducing the duration of first stage of labour without causing any maternal and neonatal complications. Materials and Methods: It was a prospective, comparative, observational study. 80 women with term pregnancies in active labour were recruited for the study. They were allocated into 2 groups, study and control group each with 40 patients. The duration of active labour was taken from 3 cm dilatation to full dilatation of the cervix. The study group received 40 mg HBB as slow I V injection (over 1 – 2 min) given at hourly intervals up to a maximum of 3 doses starting at 3 cm dilatation. Results: The mean duration of active phase of labour was 109.28 ± 58. 42 minutes in the study group and 317.48 ± 108.9 in the control group. The difference between the 2 groups was statistically significant (p< 0.001). In 25 (62.5%) women, the onset of active labour to delivery interval was < 2 hours in the study group whereas it was only 2 (5%) in the control group. Similarly 2 (5%) women took > 4 hours after first injection of HBB to deliver whereas 29 (72.5%) women took > 4 hours after onset of active labour to deliver in control group (table 5). This was statistically significant (p < 0.05). There was no difference in the APGAR scores in the 2 groups. No significant adverse effects were noted in the group of women receiving HBB. Conclusion: HBB is a safe drug and is effective in significantly reducing the duration of labour.

Keywords: first stage, hyoscine butyl bromide (HBB), labour, cervical dilatation.