Abstract

FORMULATION OF SUSTAINED RELEASE ATENOLOL MATRIX TABLETS THROUGH OPTIMIZATION AND THEIR EVALUATION

Masheer Ahmed Khan *

Abstract

The object of the present study is to develop sustained release system of the Atenolol which is β-1 cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension. The drug has a short biological half-life of six to eight hours with oral bioavailability of 50% and smaller dose of drug 50 mg. Once daily Sustained release matrix tablets of Atenolol reduces the frequency of administration and improves the patient compliance. Sustained release of the drug is devised from the matrix tablet dosage form. Atenolol matrices were prepared from different grades of hydroxylpropyl methylcellulose (HPMC) viz. combination of polymers HPMCK4M and HPMCK15M. Optimization techniques using factorial design for two factors at three levels (32 ) was selected to optimize varied response variables viz. release rate exponent (n), k, amount of drug released in 12h (Rel12h) and mean dissolution time MDT. The optimum formulation was selected and the results obtained with the experimental values were compared with the predicted values. In conclusion, the results suggest that the developed sustained-release matrix tablets could provide quite regulated release of the drug over an extended period of time.

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