Abstract

PHARMACOKINETICS AND IN VIVO EVALUATION OF BIODEGRADABLE IBUPROFEN-LOADED MICROPARTICLES: ANTI-INFLAMMATORY AND ITS ULCEROGENIC PROTECTION

*Mumuni A. Momoh, Gwarzo S. Mahmud, Musiliu O. Adedokun and Onuora I. Comfort

Abstract

The purpose of this study is improve the bioavailability, antiinflammatory and gastro-protective effect of ibuprofen using PLA as carrier. Ibuprofen loaded PLA-microparticles were formulated using solvent evaporation technique. The preparations were characterized for the flow, particle size, encapsulation efficiency and drug loading, as well as anti-inflammatory and gastro-protective activity in an animal model. Based on the in vivo study the efficacy and potency of the ibuprofen-loaded PLGA microparticles were determined and compared to that of the marketed sample as well as pure drug, The microparticles have relatively uniform particle size (231 ±0.2 μm) with relative poor flow properties. The encapsulation efficiency and loading efficiency ranges from 83.4- 89.3 and 23.4 - 30.1 %, respectively. Significant (p< 0.05) anti-inflammatory and gastroprotective effect compared to the reference samples. The ibuprofen-microparticles effectively enhanced the bioavailability, anti-inflammatory and gastro-protective effect of the incorporated drug. PLA showed a promising system for oral delivery of ibuprofen.

Keywords: anti-inflammatory, gastroprotective, microparticles, ibuprofen.