Abstract

SENSITIVITY AND CHARACTERISTIC ANALYSIS OF CORE NEEDLE BIOPSY COMPARED TO INCISIONAL BIOPSY FOR DIAGNOSIS OF GRANULOMATOUS LOBULAR MASTITIS

Amirahmad Salmasi, Mehdi Asgari, Behzad Borzui*

Abstract

Background: Granulomatous Lobular Mastitis (GLM) control and treatment is different in any disease. And, accurate pathologic and radiological symptoms are required for correct diagnosis and application of minimal invasive procedures. In this study, it is tried to determine the effectiveness of core needle biopsy in the diagnosis of GLM. Material and Method: all patients with Granulomatous Lobular Mastitis were included in the study. A total of 51 patients were selected. Data of age, parity, History of breastfeeding, history of OPC prescription, family history of breast disease, and history of autoimmune disease in patients were collected. These patients were selected between fall 2010 and fall 2011, and then, follow-up study was performed for six months to 1.5 year After collecting and recording data in statistical software spssver 19, statistical test of t-test was used to compare the results. Result: by the use of needle biopsy, 12 patients diagnosed of GLM, 44 patients diagnosed of invasive ductal carcinoma, 26 patients patients diagnosed of periductal mastitis, 12 patients patients diagnosed of fibroadenomas, 4 patients patients diagnosed of fatnecrosis, and 4 were indistinguishable (Fig. 1). All patients underwent incisional biopsy. And, in all cases where the diagnosis of GLM was not done by needle biopsy, it was completed by incisional biopsy and using incisional biopsy on 4 patients, one case of GLM, 2 cases of cancer breast, and one ductal ectasia were diagnosed. According to the obtained results, sensitivity of needle biopsyCore was 92.3%, and the characteristics of this method for the detection of GLM were 98%. Conclusions: Patients suspected of having the disease underwent the needle biopsyCore. And only those patients with negative response to needleCore or no diagnose underwent incisional biopsy. In addition, since needle biopsyCore diagnosed the disease with certainty in lumpes with sizes more than 2cm, it is recommended to employ open biopsy or ultrasound-guided needle biopsy for lumpes smaller than 2cm to increase detection accuracy. However, this finding needs further study with a larger sample size.

Keywords: Core Needle Biopsy, Incisional Biopsy, Granulomatous Lobular Mastitis.