Abstract

INDOLE: THE MOLECULE OF DIVERSE PHARMACOLOGICAL ACTIVITIES

Jonnakuti Poojitha*, Kanneti Naga Mounika, Gollapalli Naga Raju, Rama Rao Nadendla

Abstract

Indole, the bicyclic ring system consists of pyrrole ring fused with benzene ring. Although indole moiety is very small but is fascinated by scientists because of the diverse biological activities by not only indole but its various substituted derivatives as well. A large number of efforts were made to synthesize different indole compounds and their derivatives in the past decade and were found to numerous pharmacological activities like antitumor, anticonvulsant, antimicrobial, anthelmintic, antileishmanial, anti-tubercular, schictosomicidal, antifungal, anti-inflammatory antipsychotic and anti diabetic activities. Due to its wider applications in pharmaceutical industries, they will replace many existing heterocyclic based pharmaceuticals. Now days, many drugs are in the world market, while several hundred are in clinical trials. The present review focuses on the indole with potential activities that are now in development.

Keywords: Indole, Analgesic, Anticancer, Antimicrobial, Anticonvulsant.