Abstract

FORMULATION AND EVALUATION OF IN SITU GELLING OCULAR SYSTEM OF OFLOXACIN

Taranbir Singh*, Dr. Rajeev Garg, Dr. G. D. Gupta

Abstract

Ocular bioavailability is always poor is always poor from conventional ophthalmic drops due to spillage and nasolachrymal drainage may be overcome by using In-situ gels nowadays. In situ gel formation has been extensively studied to enhance ocular bioavailability and the duration of drug activity. Purpose of the present research work deal with the formulation and evaluation of in situ gelling system based on sol-to-gel transition for ophthalmic delivery of an anti bacterial agent Ofloxacin. Chitosan was used as the viscosity increasing agent in combination with Poloxamer 407 act as emulsifying and solubilizing agent. The prepared formulation were evaluated for pH, clarity, drug content, gelling capacity, in vitro drug release. in vitro drug release data of optimized formulation 12 was treated according to zero, First, Korsmeyer Peppas, Higuchi Kinetic to access the mechanism of drug release. in vitro release study comparison with marketed eye drop (Ofloxacin) was done through cellophane membrane using diffusion cell. Such as visual appearance, clarity, pH and drug content of the formulation were found in range 6.8 to 7.4, drug content was in between 92-98%, these formulation were transparent and clear. These results suggest that thermosensitive in situ gel forming material for ocular drug delivery it may increase the bioavailability, efficacy and compliance of eye drugs.

Keywords: Ocular drug delivery, in situ gels, chitosan, poloxamer, phase transition temperature.