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World Journal of Pharmaceutical Research

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Abstract

SYNTHESIS OF OCTAHYDROXYCALIX [8] ARENE DERIVATIVES

M.M.V. Ramana*, Shrimant V. Rathod and M. S. Raje

Abstract

The present synthesis relates to a novel process for preparing 2,8,14,20,26,32,38,44- octaphenyl-5,11,17,23,29,35,41,47- octa-tert butyl 49,50,51,52,53,54,55,56-octahydroxycalix [8] arene (VI); 2,8,14,20,26,32,38,44- octa (4-fluoro) phenyl -5,11,,17,23,29,35,41,47- octa-tertbutyl 49,50,51,52,53,54,55,56-octahydroxycalix [8] arene (VII):- 2,8,14,20,26,32,38,44- octa (4-methoxy) phenyl- 5,11,,17,23,29,35,41,47- octa-tertbutyl 49,50,51,52,53,54,55,56- octahydroxycalix [8] arene (VIII); 2,8,14,20,26,32,38,44- octa(3- mthoxy)phenyl 5,11,,17,23,29,35,41,47- octa-tertbutyl 49,50,51,52,53, 54,55,56- octahydroxycalix [8] arene (IX) in presence of a base.

Keywords: Octahydroxycalix [8] arene, Macrocycles, Cancer immunotherapy.

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