Abstract

SPECTRAL, ELECTROCHEMICAL AND MOLECULAR MODELING STUDIES OF SULFASALAZINE

Dr.Vijay Bhaskar and A Ramachandraiah*

Abstract

The spectral and voltammetric behavior of sulfasalazine (1H2) in aqueous buffers of varied pH is presented. Spectrophotometry and cyclic voltammetry were utilized to study its proton and electron transfer characteristics respectively. Relevant thermodynamic and electrochemical data such as deprotonation constant (pKa), charge transfer co-efficient (αna), forward rate constant (k0 f,h), etc, have been evaluated. An excellent electroanalytical assaying of 1H2 has been developed in differential pulse polarography at pH = 8. Molecular modeling on various acid-base conjugates of 1H2 and their several conformers has been carried out to arrive at the thermodynamic and conformational issues to correlate to the spectral and electrochemical observations.

Keywords: Sulfasalazine, acid-base equilibria, cyclic voltammetry, molecular modeling, conformational energy plots, isosbestic points.