Abstract

EVALUATION OF ANTICONVULSANT ACTIVITY OF PAVETTA TOMENTOSA LINN. IN MES AND PTZ INDUCED EPILEPSY

Bibhu Prasad Moharana*, Sujit Kumar Martha, Pratit Kanchan Sahu,
Ansuman Sahu

Abstract

Disease of central nervous system is appearing as a major threat in the future because of increasing mental stress, strain and work, which are essential in the developing world. Herbal drugs which are having diversified uses are always an alternative option to the synthetic drugs which are well known for their adverse effects in which the need is not met. Epileptic seizures are caused by parts of the brain eliciting abnormal electrical activity. In persons with epilepsy, there is an imbalance between excitatory and inhibitory neurotransmitters. Ethanolic extract of Pavetta tomentosa linn (200mg/kg & 400mg/kg p.o.) was studied for anticonvulsant activity on maximal electroshockinduced seizures and pentylenetetrazole induced seizures in mice. EEPT 200 mg/kg and 400 mg/kg have shown 65.20% and 70.29% protection respectively against MES induced seizures and 60.77% and 81.5% protection respectively against PTZ induced seizures. It is found that treatment with EEPT on mice significantly reduces tonic hind limb extensor stage in MES induced epilepsy & a significant increase in onset of clonic convulsions in PTZ induced epilepsy.

Keywords: Anticonvulsant, Pavetta tomentosa linn, MES, PTZ, Seizure, Mice.