Abstract

EVALUATION OF THE PHYTOCHEMICAL, ANTIPROLIFERATIVE, ANTIOXIDANT, ANTIBACTERIAL ACTIVITIES OF KALANCHOE BLOSSFELDIANA LEAVES

Manasa. G.C, Meena Kumari. P, Nagesh Muniyappa and Manohar Nanjappa*

Abstract

The present study describes the anticancer, hemolytic, antioxidant, antimicrobial activity, and phytochemical property of Kalanchoe blossfeldiana. The phytochemical screening of the petroleum ether, chloroform and methanolic extracts of K.blossfeldiana showed the presence of Alkaloids, Cardiac glycosides, Carbohydrates, Triterpenoids, Proteins, Flavonoids, Phenolic, Tannins, Quinones, Terpenoids, Coumarins, Anthocyanin, Acid, Steroids. The Antiproliferative activity of K. blossfeldiana methanolic extracts exhibited an IC50 value of 21.9 μg/ml on non-small lung cancer cell line A549 and no hemolysis was observed on human erythrocytes. DPPH radical scavenging activity and ABTS assay of the plant showed IC50 value of 54.32 μg/ml and 72.67 μg/ml respectively against standard Gallic acid. The methanolic extract of K. blossfeldiana showed significant antibacterial activity against Bacillus subtilis, Klebsiella pneumonia and Salmonella typhi with the zones of inhibition ranging from 9.0-16 mm and no activity was seen against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. These results showed that K. blossfeldiana can be a promising source for development of biologically active compounds as antitumor, antioxidant, antibacterial agent.

Keywords: K. blossfeldiana, Cancer, S. aureus, E. coli, P. aeruginosa, B. subtilis, K. pneumonia, S. typhi.