Abstract

DISSOLUTION ENHANCEMENT OF A POOR WATER SOLUBLE DRUG FUROSEMIDE BY SOLID DISPERSION TECHNIQUE

Rajendra Ayer*, Junu Khatri Silwal, Anil Prasad Sah, Nawa Raj Khadka,
Srijan Maharjan, Sanjeev Dhakal

Abstract

The aim of the present study was to enhance the dissolution rate of a poor water-soluble drug furosemide by solid dispersion technique using different hydrophilic carriers, superdisintegrants and surfactants by kneading method. Plackett Burman Design as an Experimental Design was used for screening of the carriers such as β-cyclodextrin, Mannitol, Crospovidone, Croscarmellose Sodium, Sodium Starch Glycolate, Tween 80 and Milk powder. Among the carriers, β- cyclodextrin and Crospovidone showed best effect on dissolution. For the optimization of the concentration of β-cyclodextrin and Crospovidone in solid dispersion, Central Composite Design was employed. Response surface plot, contour plot, overlaid contour plot and response optimizer plot were drawn and an optimum formulation was selected as CCD F8 which contains 40 mg (20 %) of β-cyclodextrin and 11.24 mg (5.62 %) of Crospovidone. The in-vitro dissolution study was carried in USP Type II apparatus at different time interval in different medium. The comparative dissolution profile of the optimized solid dispersion formulation, conventional drug formulation and market product of furosemide indicated that the solid dispersion product showed significantly greater dissolution. Thus solid dispersion technique is a promising technique that can be successfully employed for the enhancement of the dissolution profile of poor water soluble drug furosemide.

Keywords: Solid Dispersion, Furosemide, Dissolution enhancement, Poor water soluble drug, ?-cyclodextrin, Crospovidone.