WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

SYNTHESIS AND ASSESSMENT OF SOME NOVEL THIOPHENE AS POTENTIAL ANTIMICROBIAL SUBORDINATES

Prof. (Dr.) Kiran Mishra*

Abstract

Thiophene core has been set up as the potential element in the generally rising concoction universe of heterocyclic mixes having promising pharmacological character. A progression of tetrahydrobenzothiophene subsidiaries was incorporated with a reason to develop novel and strong antimicrobial operators of engineered inception. The required beginning material ethyl-2-amino-4,5,6,7- tetrahydro-1-benzothiophene-3-carboxylate(1) was incorporated by means of a multicomponent buildup between sulfur, cyclohexanone and ethylcyanoacetate receiving Gewald Reaction. The Compound 1 was changed into separate Schiff bases (KM1-KM4) by refluxing it with different sweet-smelling aldehydes in dioxane for 15 hours. The Schiff bases were further prepared into the last mixes i.e. thiazolidinone subordinates (KM1- KM4) by treating them with thioglycollic corrosive in vicinity of anhydrous ZnCl2 in DMF and refluxing the response blend for 4-5 hours. Combined mixes were decontaminated, described and assessed for their antimicrobial movement. A large portion of the mixes displayed moderate to critical exercises.

Keywords: antibacterial action, antifungal movement, Schiff base and thiazolidinone.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More