Abstract

PHYTOCHEMICAL AND GC-MS ANALYSES OF THE BIOACTIVE COMPONENTS OF SECURIDACA LONGEPEDUNCULATA (Fresen) ROOTS FOR ANTI-BREAST CANCER ACTIVITY

Ogukwe Cynthia Ekwy*, Okhale Samuel Ehiabhi, Ezugwu Brendan Okechukwu

Abstract

Securidaca longepeduncalata (Fresen) which belongs to the family Polygalaceae, has been known to have numerous ethno-medicinal uses. The present work evaluated the phytochemicals and bioactive components of S. longepedunculata roots extract using GC-MS analysis. Standard phytochemical analysis on the roots extract of S. longepeduncalata revealed the presence of tannins, saponins, saponin glycosides, alkaloids, flavonoids, cardiac glycosides, terpenes and steroids. GC-MS (QP2010SE) analysis of the S. longepedunculata ethanolic roots extract showed 45 components. Some of components were 1-Heptadecene (9.50%), 1-Nonadecene (6.83%), 1,2- Benzenedicarboxylic acid, bis(2-methylpropyl) ester (3.99%), 7,9-Ditert- butyl-1-oxaspiro(4,5)deca-6,9-diene (2.44%), 1-Decanol, 2,2- dimethyl- (1.43%), 5-Octadecenal (3.06%), n-Nonadecanol (5.25%), n-Tetracosanol- (5.69%), Octasiloxane 1,1,3,3,5,5, 7,7,9,9,11,11,13,1315,15-hexadecamethyl- (1.92%), 1- Pentadecene (8.40%) and Bis(2-ethylhexyl) phthalate (8.49%). The presence of various bioactive components suggest the probable use of the plant in traditional medicine for the treatment of tumour related ailments and other diseases.

Keywords: GC-MS analysis, Phytochemistry, Securidaca longepedunculata root.