Abstract

ACUTE AND SUB-CHRONIC TOXICITY OF TAMARINDUS INDICA L FRUITS' METHANOLIC EXTRACT

Rashid A. Hassouna*, Amna S. Khalid, Hassan S. Khalid and Muddathir S. Alhassan

Abstract

In-vivo experiments were performed to assess the toxicological profiles of an active methanolic extract of Tamarindus indica L (Aradaib), which showed positive effect against Salmonella typhi and paratyphi. Experiments were conducted on 40 Wister Albino rats, using 14 days for acute toxicity, with injecting a single dose of 50 mg / kg body weight, and 28 days for sub-chronic toxicity with 250, 500, 1000 and 2000 mg/kg body weight administrated orally. The obtained results revealed that there is neither acute nor sub-chronic toxicity displayed from the applied different concentrations of the active methanolic extract of Tamarindus indica L Fruits'.

Keywords: Tamarindus indica L, Salmonella typhi and paratyphi.