Abstract

COMPARATIVE STUDY ON EFFECT OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT IN FORMULATION OF FAST DISINTEGRATING TABLETS OF DICLOFENAC SODIUM

Priyanka Shrivastav*, Abhay Kumar Verma and Vandana Sethi, Arun Kumar Singh

Abstract

Diclofenac is a NSAID (Non steroidal ant inflammatory drug) which is generally taken to reduce inflammation and as an analgesic. In this study an attempt has been made to formulate a dosage form of diclofenac sodium using natural superdisintegrant Guargum to show that this natural superdisintegrant will show better disintegrating property than the synthetic superdisintegrant like sodium starch glycolate in the formulation of Fast disintegrating tablet (FDT) of diclofenac sodium. Fast disintegrating tablet prepared by direct compression technique using natural & synthetic superdisintegrant in different concentration & evaluated. Among all G2 is an optimized formulation of guargum that releases the drug above 90% with in 60 min. as compared to S2 which is a sodium starch glycolate preparation.

Keywords: Diclofenac, Fast disintegrating tablets, Superdisintegrant.