Abstract

THE IMPACT OF METFORMIN ON PSYCHOSOCIAL WELLBEING AFFECTING QUALITY OF LIFE AMONG MALAYSIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME.

M.S. Gill, M. Prabhu, Leon Cruz*, Ashwinder Singh, Leonard Cruz

Abstract

Polycystic ovary syndrome (PCOS) is proven to cause a reduction in wellbeing and quality of life. The aim of this study was to monitor the impact of metformin on mental health issues of psychosocial wellbeing affecting the quality of life among Malaysian women with PCOS. A cross sectional study was carried out at the outpatient clinic of obstetrics and gynecology (OnG) department at 2 Hospitals for 4 months by convenient and purposive sampling where 100 patients were enrolled equally into without metformin group and with metformin group, based on their pharmacotherapy for their PCOS management. Validated instrument for this study consists from combination of Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II), Rosenberg’ Self-Esteem Scale (RSES), Liebowitz’ Social Anxiety Scale (LSAS) and SF-36 Quality of Life Scale (SF-36), which was then handed out for comparison between the groups. Results indicated significant positive differences in the mean score of anxiety, depression, self-esteem, social anxiety and quality of life, of respondents in with metformin group. The changes in mean score was highest in Quality of Life (QoL), showing a higher score of 90.60 (17.60) in with metformin group compared to score of 80.40 (15.45) in without metformin group. The findings revealed that metformin had a positive impact in enhancing mental health issues of psychosocial wellbeing and quality of life among Malaysian women with PCOS.

Keywords: Polycystic Ovarian Syndrome, Metformin, Psychosocial wellbeing, Quality of Life.