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World Journal of Pharmaceutical Research

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Abstract

SYNTHESIS OF DECAHYDROXYCALIX [10]ARENE DERIVATIVES

M. M. V. Ramana*, Shrimant V. Rathod1 and M. S. Raje

Abstract

The present synthesis relates to a novel method for preparing 2,8,14,20,26,32,38,44,50,56-deca(4-nitro)phenyl-,11,17, 23, 29, 35, 41, 47, 53, 59-deca -tertbutyl- 61, 62, 63, 64, 65, 66, 67, 68, 69, 70- decahydroxycalix[10]arene(VI);2,8,14,20,26, 32,38,44,50,56-deca(3- nintro)phenyl- 5,11,17,23,29,35, 41,47,53,59-decatertbutyl-61,62,63, 64,65,66,67,68,69,70-decahydroxycalix[10]arene(VII),2, 8,14, 20,26, 32, 38,44,50,56-deca(2-nintro)phenyl-5,11,17,23,29, 35,41,47,53,59- deca-tertbutyl-61,62,63,64,65,66,67,68,69,70-Decahydroxy calix[10] arene(VIII),2,8,14,20,26,32,38,44,50,56-deca(4-cyano)phenyl-5,11,17, 23,29,35,41,47,53, 59-deca-tertbutyl-61,62,63,64,65,66,67,68,69,70 - decahydroxycalix [10] arene (IX ) in presence of base.

Keywords: Calix[10]arenes, Macrocycles, Cancer immunotherapy.

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