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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS AND FORMYLATION OF CYCLIC IMIDES USING VILSMEIER-HAACK REACTION FROM 2,6-DICHLORO-4- TRIFLUOROMETHYL ANILINE AND THEIR ANTIMICROBIAL ACTIVITY

S. S. Rajput* and R. M. Sayyed

Abstract

A simple and efficient method has been developed for the synthesis of five and six membered cyclic imides using succinic anhydride, glutaric anhydride, 2,6-dichloro-4- trifluoromethyl aniline and acetyl chloride in presence of benzene and their formylation using Vilsmeier-Haack reaction. The synthesized compound are screened for their antimicrobial activity.

Keywords: 2,6-Dichloro-4-trifluoromethyl aniline, Succinic anhydride, glutaric anhydride, Vilsmeier-Haack Reagent, cyclic imide.

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