Abstract

THE EFFECT OF THE ETHANOLIC EXTRACT OF MAERUA PSEUDOPETALOSA ROOTS AND SOLANUM DUBIUM FRUITS ON LIPID PROFILE AND BODY WEIGHT IN WESTAR ALBINO RATS

Hayder Eltaher Sulaiman*, Prof. Tarig Elhadyah, Prof. A/Wahab Hasan, Mussab Mohammed

Abstract

study was carried to evaluate the effect of the ethanolic extract of maerua pseudopetalosa roots and solanum dubium fruits on lipid profile and body weights in westar albino rats. Rats were checked for lipid profile on the zero day and then fed high cholesterol diet for two weeks and again checked for blood lipid profile. Rats were then divided into four groups each of six rats. Group one left on normal diet and water ad libitum. Group two was administered atorvastatin, group three solanum dubium fruit extract and group four maerua pseudopetalosa ethanolic root extract. The negative control group uprising gained weight through time of the study while the lipid profile change was not significant with the exception of cholesterol after the withdrawal of the high lipid diet. The positive control group (atorvatstatin), exhibited a pronounceable change in the lipid profile with significance (p≤0.05) in the LDL value. A noticeable weight and lipid profile change took place in the group administered solanum fruit extract with significance in the LDL value. Group administered maerua root extract also exhibited remarkable change in weight and lipid profile specially with cholesterol and hdl values. The study concluded that ethanolic extract of both solanum dubium fruit and maerua pseudopetalosa are quite effective in lowering blood lipid profile with comparable results of the known ethical medications. Worth to be mentioned that these results are the first to be introduced in the medical literature.

Keywords: Solanum, maerua, ethanolic extract, lipid profile, westar albino rats.