Abstract

DEVELOPMENT AND INVITRO CHARACTERIZATION OF TRANSDERMAL PATCHES OF IMIDAPRIL

Pamu Sandhya* and Syeda Shadan Samreen

Abstract

Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human body. Matrix type transdermal patches containing imidapril were prepared by solvent casting method employing a mercury substrate by using the combinations of HPMC, PEG-400 in different proportions. The transdermal patches were evaluated for their physicochemical properties like thickness, weight variation, tensile strength, folding endurance, drug content, swellability, in -vitro permeation studies. FTIR and UV studies indicated no interaction between drug and polymers. The permeability of imidapril was increased with increase in PEG-400 content. The burst effect due to the incorporation of PEG-400 was because of the rapid dissolution of the surface hydrophilic drug which results in the formation of pores and thus leads to the decrease of mean diffusional path length of the drug molecules to permeate into dissolution medium and higher permeation rates. The in vitro drug permeation followed higuchi kinetics as its coefficient of correlation values predominates over zero order, which indicated fickian transport diffusion. Among all the prepared patches F8 would be better formulation based on the in vitro permeation studies. Based on the above observations, it can be reasonably concluded that HPMC, PEG-400 polymers are better suited for the development of transdermal patches of imidapril.

Keywords: Transdermal patches, imidapril, in vitro permeation, HPMC, PEG-400.