Abstract

DIABETIC NEPHROPROTECTIVE ACTIVITY OF HYDRO ALCOHOLIC STEM EXTRACT OF MORUS ALBA AND LANTANA CAMARA IN STREPTOZOTOCIN INDUCED DIABETIC NEPHROPATHIC IN RATS.

Sundeep K.*, Somanathan S. S.* Jerusha Rani V. and Ranganayakulu

Abstract

Herbal drugs have been the predecessors of all medicines. Mankind has been using several herbal medicines to cure several diseases and relieve from physical sufferings. The knowledge of herbal drugs are innovative and critical since the ancient days. The current study objects to evaluate the diabetic Nephro protective activity of hydro alcoholic stem extract of morus alba leaf extract and lantana camara leaf extract(HAML) in streptozotocin induced diabetic nephropathy in rats by evaluating and assessing parameters like animal body weight, Fasting Blood Glucose(FBG), lipid profiles like Total protein, HDL, LDL, VLDL, Triglycerides, Albumin, blood urea nitrogen (BUN), Creatinine, Uric acid and in-vivo antioxidant parameters which include SOD, Catalase, GSH, LPO and histopathology of the kidney tissues. The experimental animals were grouped as 1) Normal -Vehicle treated (normal saline), 2) Disease control (STZ) 3) Standard (STZ + Glibenclamide (5mg/kg) and 4) Test-I (STZ + HAML (100mg/kg.) and 5) Test-II (STZ + HAML (200mg/kg.). The results have shown an excellent nephroprotection action with the high dose of HAML.

Keywords: Herbal drugs , Nephro protective, lipid profiles, in-vivo antioxidant.