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Abstract

STABILITY-INDICATING HPLC DETERMINATION OF ARTEMETHER IN BULK DRUG AND PHARMACEUTICAL FORM

*Milind Ubale and Vilas Choudhari

Abstract

An accurate and precise liquid chromatographic method was developed for the simultaneous estimation of Artemether in bulk drug and pharmaceutical form. The chromatographic analysis was performed on Purospher STAR C-18 250 x 4.0 mm 5μm or equivalent with mobile phase consisting of Acetonitrile and water (pH- 3.0) in the ratio 62:38 v/v, at a flow rate of 1.5 ml/min and eluent monitored at 216nm. The retention time for Artemether was found to be 14.641 minutes. The proposed method is simple, accurate and precise and could be successfully employed in routine quality control for the simultaneous estimation of Artemether in bulk drug and pharmaceutical form.

Keywords: Artemether, RP-HPLC, Mobile phase, Column etc.


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