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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BILAYER BUCCAL TABLET OF SUMATRIPTAN SUCCINATE

Manisha R. Pundge*, Prafull P. Patil, Dr. Shashikant D. Barhate

Abstract

Objective: To develop mucoadhesive bilayer buccal tablet of Sumatriptan succinate as controlled release tablet to enhance its bioavailability and reduce its frequency of dose. Method: Sumatriptan succinate tablets were prepared with natural mucoadhesive polymer Sodium alginate, alone had the bioadhesive forces suitable for buccal bioadhesive tablets, with slightly reducing its strong mucoadhesive property by addition of HPMC,to prevent from damaging of skin due to strong mucoadhesive property of Sodium alginate.50mg backing layer compressed to control the release of drug from tablet. Ideal batch shows maximum mucooadhesive time and maximum mucoadhesive strength of 13.10g Results : The selected batch F3 and F6 shows maximum releas up to 99% and 98% in 6hrs. Conclusion: Mucoadhesive bilayer buccal tablet of Sumatriptan succinate improve bioavailability. A combination of polymer Sodium alginate: HPMC shows good drug release as compaire to other batches.The ratio of both polymer was taken as 2:1 showing maximum drug release. These both polymer combinations show good mucoadhesive strength, good permeation also.

Keywords: Bilayer buccal tablet of Sumatriptan succinate, mucoadhesive strength, Sodium alginate, in vitro permeation study.


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