Abstract

ANTI-FOLLICLE STIMULATING HORMONE ANTIBODIES IN POLYCYSTIC OVARY SYNDROME AND APPEARANTLY HEALTHY CONTROLS

Dr. Haneen Akram*

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by hormonal imbalances. The syndrome is suspected as autoimmune disease. In this study, one handered hormonally and clinically characterized polycystic ovary syndrome (PCOS) patients ranging in age from 18-44 years and fifty appearently healthy controls were enrolled. The patients and controls were sera-screened for anti- FSH antibody by established enzyme-linked immunosorbent assay (ELISA), besides the specificity of anti-FSH antibody was investigated. The results emerged from this study reveal that anti-FSH autoantibody detection in patients secretors and non-secretors compared to respective controls showed that both secretors in patients and controls gave anti-FSH antibody(0.2±0.145 versus0.192±0.113) in patients and controls secretors respectively, however non-secretors showed a decreased level of anti-FSH autoantibody in patients compared to controls non-secretors(0.119±0.036 versus 0.254±0.148) in patients and controls non-secretors respectively and the test was significant at p=0.006. Part of anti-FSH was hormone specific as demonstrated by free-hormone inhibition ELISA.

Keywords: handered hormonally, appearently healthy, immunosorbent.