WJPR
World Journal of Pharmaceutical Research
( An ISO 9001:2015 Certified International Journal )
An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
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WJPR Citation
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| All | Since 2020 | |
| Citation | 8502 | 4519 |
| h-index | 30 | 23 |
| i10-index | 227 | 96 |
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Abstract
DEVELOPMENT AND VALIDATION OF EFAVIRENZ IN BULK DRUG AND FORMULATION BY RP-HPLC METHODHaneef1, Humera sultana1, Tharun goud1, Pavan Kumar Pindi2*
1Department of Pharmaceutical sciences, University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar 2Department of Microbiology, Palamuru University, Mahabubnagar, India-509001
Abstract Aim: A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validation of Efavirenz in its pure form as well as in tablet dosage form. Method: Chromatography was carried out on a symmetry C18 (4.6 x 150mm, 5μm) column using a mixture of methanol and phosphate buffer (65:35 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 245 nm. Results: The retention time of the drug was 2.48 ±0.02min. The method produce linear responses in the concentration range of 20-80mg/ml of Efavirenz. The method precision for the determination of assay was below 2.0% RSD. Conclusion: This method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: [Full Text Article] [Download Certificate] |
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