Abstract

EVALUATION OF ADIPONECTIN HORMONE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

*Professor Dr. Nawal Khairy AL-Ani, **Assistant. Professor Dr. Sabah Mahdi Hussain, *Dr. Osama Abdul W. Al-lami

Abstract

Background: Polycystic ovary syndrome (PCOS) is common complex endocrine disorder affects5-10% of women during reproductive age 30%-75% of cases of pcos associated with central obesity is often due to increased visceral fat unified metabolic dysfunction of the syndrome. Adiponectin is a cytokine produced and secreted exclusively from adipose tissue but the relationship between Adiponectin & PCOS remains controversial. The objective of this study is to evaluation Adiponectin and luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T) concentration in women with PCOS Ninty infertile obese women {obesity class BMI1- 11} within age range {15-35years} subdivided according to Rotterdam criteria to 69 women with PCOS and 21 non PCOS. They were prospectively recruited for this study from Infertility diagnosis outpatient clinic centre in south of Iraq myssan during a period from April-2014 to November 2014. All women agreement to be fasted over night for venous blood sample drain at the morning of the 2nd day of cycle to estimate plasma Adiponectin, LH, FSH and T. Measurements of weight in kg, height in meter waist circumference in cm, hip circumference in cm, was done for calculation of body mass index (BMI) kg/m2 & W/h. The mean serum value of ADP in non PCOS was higher than of PCOS (17,8ng/ml± 6.38 vs 4.2ng/ml±2.53) with a significant association (P value =0.0001), In conclusion Hypoadiponectinemia is evident in obese infertile women with PCOS as well proportional indirectly with W and W/H which is indicator of visceral obesity & associated of metabolic risk Hypoadiponectinemia was highly significant correlation with primary infertility which is associated abnormalities of PCOS.

Keywords: PCOS, ADP, ELISA, LH, FSH, T, W. W/h, BMI.