Abstract

MEMANTINE EFFECTS ON INSULIN RESISTANCE IN ALZHEIMER’S DISEASE

Mehdi Maghbooli, Hossein Chiti, Nafiseh Jabbari Daneshvar, Maryam Jameshorani, Masoud Asadi-Khiavi*

Abstract

Background: Insulin resistance is a risk factor for Alzheimer’s disease (AD). Deficit in insulin metabolism can lead to the deterioration of the clinical course of AD. Furthermore, Memantine have revealed remarkable clinical efficacy. This study was designed to study of insulin resistance and Memantine relationship in AD. Patients and Methods: Fifty six AD patients were enrolled in this study at Zanjan Vali-e-Asr university hospital. They were randomly divided in two groups based on receiving Memantine or placebo in associated with standard therapies for both groups. AD diagnosis was confirmed using the standard criteria. Treatment continued for one month. Anthropometric parameters, serum Triglyceride, Total Cholesterol, HDL, fasting insulin and Blood Sugar were measured before and after treatment. Insulin resistance was calculated using the HOMA (Homeostasis Model Assessment) index. Results: There was no correlation between HOMA index variations and Memantine consumption; however, patients aged 70 years and older had lower insulin resistance. Significantly decrease in hip and waist circumference was observed in the Memantine using group. The HOMA index and severity of AD did not show any significant correlation. Conclusions: One month Memantine therapy did not significantly provide alteration on insulin resistance level. It seems to further studies are needed for this issue.

Keywords: Insulin resistance, Memantine, Alzheimer’s disease.