Abstract

NOVEL MULTIPARTICULATE DRUG DELIVERY APPROACHES FOR COLON TARGETING: A COMPREHENSIVE REVIEW

Sukhbir Kaur*R. K. Narang and T. R. Bhardwaj

Abstract

An intestinal single celled parasite, Entamoeba hystolytica, is the major cause of morbidity and mortality in the developing countries which are having poor sanitary condition. It is highly pathogenic freeliving amoebae, protease of these amoeba are highly virulent influencing the immune system of the host. The parasite exists in two forms i.e. cyst and trophozoites. Trophozoites form of the protozoa invades mucus membrane of colon and destroys the underline tissue. The treatment approaches against amoebiasis are normally based on conventional approaches. With the understanding of the pathogenesis of disease and current advancements in the novel drug delivery system, the researcher across the globe are actively participating in the novel treatment approaches against amoebiasis. The unique capability of pH sensitive, mucoadhesive and mucopenetrating delivery system have opened a new avenue against disease. The current review highlights the role and contribution of novel drug delivery system in the delivery of the drugs in the colon.

Keywords: Entamoeba hystolytica, colon targeting, pH sensitive delivery system, mucoadhesion, mucopenetration, nanoparticles.