Abstract

EFFICIENT SYNTHESIS OF NOVEL DIORGANYL SELENIDES VIA CLEAVAGE OF SE–SE BOND OF DISELENIDES BY RUCL3/ZN AND SCREENED FOR THEIR BIOLOGICAL EFFICACY

Ashok B, Kumar Naik K H, Avinash P and Nagaraja Naik*

Abstract

The RuCl3-catalysed cross-coupling reaction of novel diorganyl diselenides with benzyl halides using Zinc as an additive. This crosscoupling reaction was performed with amide conjugated diaryl diselenides with benzyl halides bearing electron-withdrawing and electron-donating groups, affording corresponding diaryl selenides in good yield and further characterized by using Mass, 1H NMR, 13C NMR, 77Se NMR and elemental analysis. The title compounds were evaluated for their in vitro Antioxidant and Antibacterial activity.

Keywords: Diselenides, RuCl3/Zn cleavage, Diorganyl Selenides, Organoselenium compounds, Antioxidant activity, Antibacterial activity.