Abstract

DESIGN OF TRAMADOL HYDROCHLORIDE LOADED SOLID LIPID NANOPARTICLES BASED GELS FOR PAIN MANAGEMENT

Akkshata Parab* and Amrita Bajaj

Abstract

Objective: To formulate and characterize Tramadol hydrochloride loaded Solid Lipid Nanoparticles based gels, to understand in vitro drug diffusion profile and evaluate the developed formulations for topical application for pain management. Materials and Methods: Precirol ATO 5, Compritol 888 ATO and Tween 80 were used to prepare the Tramadol hydrochloride loaded Solid Lipid Nanoparticles based on solvent evaporation method and characterized using Zetasizer, Scanning electron microscopy and Differential scanning calorimetry. Tramadol hydrochloride loaded solid lipid nanoparticles were prepared and then incorporated in gel base for topical delivery. Results: The nanoparticles were in the size range of 300-400nm with zeta potential between -20 to -30mV. The SLN exhibited circular structure with better encapsulation efficiency. Sustained release topical gel of Tramadol hydrochloride lipid nanoparticles was prepared using the lipids Precirol ATO 5, Compritol 888 ATO with Tween 80 as surfactant by solvent evaporation method. Drug release followed diffusion controlled kinetics and released the drug for prolonged periods with enhanced dermal penetration. Conclusion: Gel formulation of Tramadol hydrochloride SLN is promising approach for prolonging the topical residence time and thereby better therapeutic effects.

Keywords: Entrapment efficiency, Solid Lipid nanoparticles, Surfactant, Sustained release.