Abstract

ANTISPERMATOGENIC ACTIVITY OF LATER TRANSITION METAL COMPLEXES OF BENZOTHIAZOLINES DERIVED FROM SUBSTITUTED COUMARINS IN MALE RATS

Puja Kapoor, S. C. Joshi, R. V. Singh and Nighat Fahmi*

Abstract

Biologically active sulfur donor ligands 3-acetylcoumarin benzothiazoline and 3-formyl-4-chlorocoumarinbenzothiazoline and their lanthanide metal complexes were synthesized, characterized and examined for their antifertility activities. The present investigation was conducted to reveal the effect of later transition metal complexes on the reproductive organs of male rats. In male rats, dose level of 30 mg/kg of ligands and their metal complexes was administrated for 60 days which caused a significant decline in the weight of reproductive organs. Negative fertility in treated rats was seen in fertility test .The treatment has also shown decline in the sperm motility and density significantly. A significant lowering in glycogen, protein and sialic acid and an increase in cholesterol content of testes were noticed. Present study indicated that ligands and their lanthanide metal complexes showed antifertility effects on male reproductive functions.

Keywords: 3-acetylcoumarinbenzothiazoline,3-formyl-4-chlorocoumarinbenzothiazoline, spectral studies, antifertility activity.