Abstract

FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF CELECOXIB

P. Sai Priyanka*, V. Hemalatha, P. Pravin Sri Kumar, M. Ranga Lakshmi Naidu

Abstract

The Aim of the present work is to formulate and evaluate an oral pulsatile drug delivery system to achieve time release of celecoxib, based on Chronopharmaceutical approach as NSAIDS. Pulsatile delivery system is capable of delivering drug when and where it required most. Time-delayed tablets, designed to release drug after a predictable lag time, are intended for oral chronotherapy. The basic design consists of a core tablets prepared by wet granulation method. The tablets were coated with an inner swellable layer containing HPMC K100M, guar gum, xanthan gum. The prepared pulsatile tablets were evaluated for the drug content, thickness and in-vitro release profile, etc. In-vitro release profiles of pulsatile device during six hours studies were found to have very good sustaining efficacy. During the first five hours it shows minimum drug release and at the end of six hours immediate release was observed. Increasing the level of the rupturable layer increased mechanical strength and retarded the water uptake and thus prolonged the lag time. Stability studies proved that coating of tablets seems to decrease the effect of temperature and moisture on the degradation of celecoxib. The programmable pulsatile release has been achieved from tablet over a 7-8 hr period, consistent with the demands of chronotherapeutic drug delivery.

Keywords: Pulsatile Drug Delivery; Celecoxib, Sodium, Starch Glycollate, Lactose, Talc, Magnesium Stearate, Crosspovidone, Croscarmellose Sodium, HPMC K100M.