Abstract

EFFICIENT ULTRASOUND SYNTHESIS AND BIOLOGICAL SCREENING OF METAL COMPLEXES OF N-(4- METHOXYBENZYLIDENE) ISONICOTINOHYDRAZONE

Ganesh S. Kulkarni, Priyanka L. Anandgaonker, Digambar D. Gaikwad, Dnyandeo M. Janrao*

Abstract

Here we report the synthesis of three new complexes of Ni(II), Zn(II) and Co(II) with the ligand N-(4-methoxybenzylidene) isonicotinohydrazide, having the formula [M((LA))(ac)2]xH2O (M = Ni(II), Zn(II) and Co(II)) with their characterization. The ligands were synthesized by the condensation of isonicotinic acid hydrazide with 4- methoxybenzaldehyde. The complexes were synthesized by using ultrasound irradiation method and were characterized by elemental analysis, FTIR, UV-Vis spectroscopy, molar conductivity and evaluated for their in vitro antibacterial activity against human pathogens like gram negative Escherichia coli (E.coli), Salmonella Typhi (S. typhi) and gram positive Bacillus Subtilis (B. subtilis), Staphylococcus aureus strains. The result indicates that in all complexes, ligand was coordinated to metal via N and O donor and having moderate antimicrobial activity.

Keywords: 4-methoxy benzaldehyde, isoniazid, ultrasound irradiation method, transition metal complexes, human pathogens, antimicrobial activity.