Abstract

ORGANOSILICON COMPLEXES AS GOOD FERTILITY INHIBITOR: EFFECT OF (N′ - [1-2-OXO-2H-CHROME-3YL-ETHYLIDENE]- HYDRAZINECARBODITHIONIC ACID BENZYL ESTER) AND ITS ORGANOSILICON COMPLEX ON SEX HORMONES AND TESTES HISTOPATHOLOGY IN MALE ALBINO RATS.

Sheenam Watts and R. V. Singh

Abstract

The present study was designed to synthesize and characterize the ligand (N′ -[1-2-oxo-2H-chrome-3yl-ethylidene]- hydrazinecarbodithionic acid benzyl ester) and its organosilicon complex and also to evaluate their antifertility potentials. The tested doses were given orally to the male albino rats for 45 days at the dose level 30 mg/kg. b.wt./day. Findings of the present investigation mention a decrease in the weight of testes, epididymis, vas deferens, and seminal vesicle and highly significant decrease in testosterone, follicle stimulating hormone (FSH) and leutinizing hormone (LH). Histopathological changes in testes were also studied which show many degenerative changes i.e. spermatogenesis, disruption in normal epithelial organization, decreased number of elongated sperm, depletion in germinal layer and dilatation of interstitial space. In conclusion the study shows that ligand (N ′ -[1-2-oxo-2Hchrome- 3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester) and its silicon complex alter the sex hormones and fertility in rats.

Keywords: Organosilicon Complex, Radioimmuno Assay, Spectral Studies, Hormones, Fertility Inhibitor.