Abstract

FORMULATION AND EVALUATION OF ETHOSOMES OF CLOBETASOL PROPIONATE

Pandey Richa*, Sharma Dinesh Kumar and Singh Arun Kumar

Abstract

Ethosomes are vesicular drug delivery systems. “Ethosomes are ethanolic liposomes”. Ethosomes are lipid vesicular structure containing phospholipids, alcohol in relatively high concentration, propylene glycol and water. Ethosomes can entrap drug molecule of various physicochemical characters such as hydrophilic, lipophilic or amphiphilic in nature. The size range of ethosomes may variate from tens of nanometers to microns. The advantage of ethosomes over other topical delivery includes enhanced permeation of drug molecules to the skin and through the skin to the systemic circulation. Better patient compliance. Better stability and solubility of many drugs as compared to conventional vesicles. Relatively smaller size as compared to conventional vesicles. Composition and components of ethosomes are safe, they have various applications in pharmaceutical, veterinary and cosmetic field. Clobetasol propionate is a synthetic corticosteroid, for topical dermatologic use. It is derived from prednisolone with low mineralocorticoid activity and high glucocorticoid activity. Corticosteroids are therapeutic agents generally used in the treatment of skin disorders such as psoriasis and eczema. As research shows that stratum corneum is the main barrier for topical absorption of drug. Topical application of drug at pathological sites offers possible advantages of delivering the drug directly to the site of action. The present study aim to formulate and evaluate ethosomes of clobetasol propionate. Ethosomes of clobetasol propionate was successfully prepared by cold method and characterized by pH, size, zeta potential, drug content, drug entrapment, in-vitro drug release and formulation F9 was found to be best from all the formulations prepared.

Keywords: Ethosomes, liposomses, ampiphillic, glucocorticoid, stratum corneum, topical, in-vitro.