Abstract

SYNTHESIS OF 5-ARYL/ALKYL-1,3,4-THIDIAZOLE-2- AMINE&THEIR DERIVATIVES USING ARYL /ALKYL NITRILES AND STUDY OF THEIR ANTIMICROBIAL ACTIVITY

Sushama S. Kadam* and G. M. Nazeruddin

Abstract

Thiadiazole is a versatile moiety that exhibits a wide variety of activity due to the presence of N=C-S present 1,3,4-thidiazole in the ring. They have become an important class of heterocyclic compounds of great interest of researches because of their broad types of biological activity. In the present research work reported an efficient way to synthesize of 5-phenyl/benzyl-1,3,4-thidiazole-2-amine and their derivatives from Aryl nitriles. The structures and elemental analysis of novel synthesized derivatives were confirmed by various ways of spectral analysis. Study of antimicrobial property was done by Kirby Bauer Disc diffusion method using standard antibiotic chloroamphenicol.

Keywords: Heterocyclic compounds, 5-phenyl/benzyl-1,3,4- thidiazole-2-amine, chloroamphenicol, antimicrobial etc.