Abstract

FORMULATION AND IN-VITRO EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF FUROSEMIDE

Srijan Maharjan*, Junu Khatri Silwal, Anil Prasad Sah, Rajendra Ayer, Nistha Amatya, Nawa Raj Khadka

Abstract

The aim of the present study was to enhance the solubility and dissolution of poor water soluble drug Furosemide by formulating into Self Emulsifying Drug Delivery System. Self-Emulsifying Drug Delivery System (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water soluble drugs. Self-emulsifying formulations are isotropic mixtures of drug, lipids (natural or synthetic oils) and emulsifiers (solid or liquid), usually with one or more of hydrophilic co-solvents/co-emulsifiers. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro or nano emulsions containing the solubilized drug. The solubility of Furosemide was determined in various vehicles such as Water, Tween 80, Tween 20, Oleic Acid, Sunflower Oil, PEG 400 and Glycerol. Furosemide was found to be more soluble in Tween 80 (Emulsifier), PEG 400 (Co-surfactant) and Oleic Acid (Oil) and was selected to formulate SEDDS. Sixteen different formulations varying the proportion of Oleic Acid, Tween 80 and PEG 400 were prepared. Effects of lipids and surfactants on physical properties of SEDDS such as in vitro emulsification efficiency in terms of selfemulsification time, emulsion droplet size, percent transmittance and dissolution profile were measured. From the evaluations it was observed that the higher proportion of surfactant (Tween 80) significantly increased dissolution of Furosemide while decreasing emulsion droplet size and emulsification time. The SEDDS formulation of Furosemide showed faster and better release profile than market conventional tablets of Furosemide.

Keywords: Self-emulsifying drug delivery system, Furosemide, Bioavailability enhancement, Emulsion droplet size, in-vitro drug release