Abstract

A REVIEW ON ANALYSIS OF ASSOCIATION OF GENETIC POLYMORPHISM OF CYP2C19 AND P2Y12 WITH PHENOTYPIC RESPONSE OF CLOPIDOGREL IN HEALTHY VOLUNTEERS SAMPLES

Sahil S. Satam*, Omkar V. Pokharkar, Anuj Thapar, Aman Zalawadia

Abstract

Clopidogrel being used as one of the major drugs used in the treatment of Acute Coronary Syndrome, along with Aspirin it is the standard of care in such cases along with stenting, when a long term dual antiplatelet treatment is needed. The responses to clopidogrel have recently shown a wide inter-individual variation. Previous studies have shown that few polymorphisms in the CYP2C19 and P2Y12 gene affect the platelet aggregometry response to Clopidogrel. This in return increases the risk of recurrent thrombotic events in patients who are poor responders to clopidogrel. Thus it has become crucial to determine the relationship between these polymorphism and response to Clopidogrel. The association in patients with these polymorphism and actual clinical response in normal healthy human volunteers in Indian population has not yet been studied extensively. This review paper helps in analysing and associating genetic polymorphisms of CYP2C19, P2Y12 and response to Clopidogrel in normal healthy participants. A significance association has been found that between genetic polymorphisms of CYP2C19, P2Y12 and Clopidogrel response, using general statistical methods.

Keywords: clopidogrel, CYP2C19, P2Y12, Indian population.