Abstract

OPTIMIZATION OF ETHYL CELLULOSE CONCENTRATION IN EXTENDED RELEASE FORMULATION OF HYPOGLYCEMIC AGENT

Amit Kumar*, Peeyush Sharma, Ramandeep Grewal, Rambabu Sharma and Anil Bhandari

Abstract

The aim of the present investigation was to optimize the effect of ethyl cellulose (EC) concentration in extended release solid dispersion formulations of Glibenclamide (GLB) with using polyvinyl pyrrolidone (PVP) as a hydrophilic release retardant polymer. Glibenclamide is a oral hypoglycemic agent having short biological half-life of 3-4 hrs and therefore extended release medication is required to get prolonged effect. A 23 full factorial design were used for formulation composition and all formulations were developed using solvent evaporation method. The in vitro release studies were performed using US Pharmacopoeia type II apparatus (paddle method) in 900 ml of pH 7.4 phosphate buffer at 100 rpm. The release profiles were analyzed using statistical method (one-way analysis of variance) and similarity factor (f2) values. The results in the present investigation confirm that the release rate of the drug with PVP solid dispersion is highly influenced by the drug/EC ratio. The formulation F2 containing EC and PVP (1:1) was found to be promising. Formulation F2 showed maximum drug release in 8 hrs along with satisfactory extended release mechanism. The developed extended release formulation of Glibenclamide may be used in clinic for prolonged drug release in stomach for at least 8 hrs, thereby improving the bioavailability and patient compliance.

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