Abstract

A REVIEW ON FLOATING DRUG DELIVERY SYSTEM

Ranjeet Kumar Bhargav*, Rehana Parveen, Abhay Kumar Verma,
Priyanka Shrivastav

Abstract

The objective of our review is to compile the recent advancements and literatures regarding the novel dosage form i.e. the floating drug delivery systems (FDDS) that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. Floating drug delivery system provides local delivery to specific region like stomach and proximal small intestine and it’s also shows better bioavailability and improved therapeutic activity and substantial benefits to patients. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. Gastro retentive dosage forms (GRDF) has achieved significant interest in the past few years because some limitations encountered with conventional and oral controlled release drug delivery system can be avoided. Effervescent floating drug delivery systems release gas (CO), thus reduce the density of the system 2 and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. In the present article we will discuss mechanism of effervescent floating drug delivery system, some marketed product related to this as well as various patents on this.

Keywords: Floating, Prolonged, Gastro retentative, Efervescent.