Abstract

NEUROINFLAMMATION: NEUROPATHOLOGICAL AND CLINICAL CORRELATES

Sarvesh S. Maurya, Vishal Thakur, Rachana D. Sarawade

Abstract

Neuroinflammation is central to the common pathology of several acute and chronic brain diseases. The neurotoxic role of microgliaderived inflammatory mediators which are suspected to hasten the death of nigral dopaminergic neurons, in particular the proinflammatory cytokine Tumor Necrosis Factor (TNF) and its downstream signaling pathways. The possibility that chronic microglia activation links proteinopathies to neurodegeneration. This review examines the consequences of excessive and prolonged neuroinflammation, particularly its damaging effects on cellular and brain function, as well as its relevance to disease progression and possible interventions. The evidence gathered here indicates that neuroinflammation causes and accelerates long-term neurodegenerative disease, playing a central role in the very early development of chronic conditions including dementia. The wide scope and numerous complexities of neuroinflammation suggest that combinations of different preventative and therapeutic approaches may be efficacious.

Keywords: Neuroinflammation, microglia, chemokines, parkinson?s disease.