Abstract

ANALGESIC ACTIVITY OF AQUEOUS EXTRACT OF LEAVES OF TURNERA DIFFUSA

Divya Bade*, Shivashankaramurthy K. G., Apoorva B. M., Sonali Mohanty, Nayana M. R.

Abstract

Pain is a disabling component accompanying many medical conditions. Analgesics are the drugs which relieve pain by acting either centrally or peripherally. As most of the analgesics are associated with adverse effects, natural products having analgesic activities seem promising as the side effects might be minimal. Turnera diffusa is a plant which has established aphrodisiac properties. Many other properties of T.diffusa are being studied including its analgesic activity. This is one of such studies. Aim: To study analgesic activity of Turnera diffusa. Methods: Analgesic activity is studied using hot plate method and tail clip method with doses of 25mg/kg, 50mg/kg and 75mg/kg of Turnera diffusa and compared with saline as control and tramadol as standard drug. Objectives: 1) To study the analgesic property of T.diffusa leaves and 2)To compare it with that of Tramadol. Results: T.diffusa showed significant analgesic activity at all doses compared to the control group. Its analgesic activity is comparable to that of the standard drug.

Keywords: Turnera diffusa, Analgesic, central pain models.