Abstract

NEUROPROTECTIVE ACTIVITY OF SEEDS OF CAESALPINIA BONDUCELLA (ROXB) IN OXIDATIVE STRESS INDUCED RATS

Shamabai D. Hosamani*, Dr. Shivakumar S. Inamdar, Ravi Ranjan Kumar Pandey, Pallavi P. Kulkarni and Harika Vatikuti

Abstract

Stroke is one of the important causes of mortality and morbidity in the world. The treatment of stroke is out most important. Herbal drugs have gained lot of acceptance in the recent years because they have a relatively higher therapeutic window, less serious side effects, and are economical. Hence we evaluate the neuroprotective activity of seeds of Caesalpinia bonducella (Roxb) in induced rats. Objectives: Neuroprotective activity of Caesalpinia bonducella (Roxb) against ischemia reperfusion induced brain injury in rats. Methods: We studied the effect of extracts of Caesalpinia bonducella (Roxb) 200 mg/kg oral doses. Albino Wister rats of either sex weighing between 150-200 g were divided into six groups of six animals of each. Evaluated the neuroprotective effect of Caesalpinia bonducella (Roxb) was carried out by using the global cerebral ischemia/reperfusion model by bilateral carotid artery occlusion for 30 min followed by 24 h reperfusion. The biochemical parameters, which were measured in animals brain were lipid peroxidation(LPO), superoxide dismutase(SOD), catalase, glutathione, total thiols and total proteins of induced and treated groups. Result: The interpretation of results were done using statistical analysis by One-Way Analysis of variance (ANOVA) followed by Dunnet‟s„t‟ test. This model showed reduced in the level of lipid peroxidation, an increase in the level of superoxide dismutase, catalase, glutathione, total thiols and total proteins. Conclusion: The methanolic and aqueous extract of Caesalpinia bonducella (Roxb) has shown significantly neuroprotective activity compare to the standard drug (Vitamin E) but Petroleum ether has shown less significantly neuroprotective activity compared to the standard drug (Vitamin E).

Keywords: Neuroprotective activity; Caesalpinia bonducella (Roxb); Stroke.