Abstract

DEVELOPMENT AND EVALUATION OF METOPROLOL SUCCINATE MICROPARTICLE-HYDROCHLOROTHIAZIDE SUSTAIN RELEASE MATRIX TABLET

Prajakta A. Ahire*, Harshada Deoghare, Rajendra Surawase, Avish Maru

Abstract

This study reports the properties of Tableted microparticles based on ethyl cellulose blend polymers as sustain release system for Metoprolol succinate. Ethyl cellulose blend microparticles are prepared through a solvent evaporation process which is widely used microencapsulation technique in the pharmaceutical industry. The Microparticle were spherical & free flow in nature. The Entrapment Efficiency was based on the ratio of polymer in formulation. The Tableted Microparticle based on 1:3 ratios was found to better formulation. Since they exhibit effective sustain release compare to other formulation. The blend microparticles of Metoprolol succinate were compressed with combination of Hydrochlorothiazide. This fixed dose combination of Metoprolol succinate and Hydrochlorothiazide is used as Antihypertensive agent. Drug Release from compressed tablet was always faster than from uncompressed Microparticles. The Drug release rate increased at higher compression pressure due to the rupture of a greater proportion of Microparticle. Generally the least compression pressure that gives Tableted with acceptable properties is preferred.

Keywords: Microparticles, Metoprolol succinate, Hydrochlorothiazide, Sustain Release Matrix Tablet.