Abstract

MOLECULAR DOCKING STUDIES OF SOME NOVEL BENZOFLAVANONE AND BENZOFLAVONE DERIVATIVES ON ENTEROTOXIN A OF STAPHYLOCOCCUS AUREUS

Manju Kumari* and Birendra Kumar

Abstract

In this work, we collected the three dimensional structure of Enterotoxin A from Staphylococcus aureus which plays an important role in staphylococcus pathway. The protein structure was collected from PDB data bank. From the 3D structures of the proteins, the targeted derivatives were designed. Docking studies was performed with designed compounds. The compounds docked to the protein by hydrogen boding interactions and these interactions play an important role in the binding studies. Docking results showed the best compounds among the derivatives.

Keywords: Antibacterial activity, docking studies, enterotoxin A.