Abstract

PYRIMIDINE HYDRAZONES AS POTENT ANTICONVULSANT

Srivastav Sanchit*, Shukla Chhama, Luhach Kanishk, Pandeya S. N.

Abstract

Pyrimidine constitutes an important class of heterocycles in drug discovery & is very well known for their anticancer, antimicrobial, antioxidant & antiviral activities. Hydrazones is a class of organic compounds with the structure R1R2C=NNH2. They are formed usually by the action of hydrazine on ketones or aldehydes & have efficient CNS depressant, analgesics activity. In the same context, Schiff bases of pyrimidne hydrazones were prepared by the reaction of “4-(4- Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5- carboxylic acid hydrazide” with citral, camphor, furfuraldehyde & menthone individually by refluxing them in the presence of glacial acetic acid (as solvent) for at least 2hrs to yield their respective derivatives. Some of the compounds shown potent and efficient anticonvulsant action as mentioned in paper. All the drugs were tested on mice at 30mg/kg body weight and reported in the paper. In addition to this, the present studies revealed that the Schiff bases derivatives of Pyrimidine hydrazone could be used to synthesize the compounds having potent biological activities such as anticonvulsants. All the synthesized compounds were evaluated at the dose of 30mg/kg body weight using Isoniazid induced model and Thiosemicarbazide model for their anticonvulsant activity which were found to be pharmacologically active.

Keywords: Pyrimidine Hydrazones, Anticonvulsant pyrimidines, Pyrmidine Hydrazones as anticonvulsant etc.