Abstract

GASTRORETENTIVE DOSAGE FORMS AS ORAL CONTROLLED DRUG DELIVERY: A REVIEW

Pamu Sandhya*, C. V. S. Subrahmanyam and K. S. K. Rao Patnaik

Abstract

Profound research has began in the field of oral controlled drug delivery systems about 30 years ago, to deliver the drug to the affected site in a pre determined and predicted rate. Gastroretentive drug delivery systems are one of a kind, which offers several advantages besides providing better bioavailability to poorly absorbed drugs and a required release profile thus attracting interest of pharmaceutical formulation scientists. Here we have discussed about factors controlling gastric retention of dosage forms, motility patterns of the GIT, applications of floating drug delivery systems, floating drug delivery systems, bio/muco-adhesive systems, raft forming systems, swelling and expanding systems and magnetic systems which are aimed for gastric retention and various factors involved in their efficiency.

Keywords: Gastroretentive drug delivery systems, bioavailability, floating drug delivery systems, bio/muco-adhesive systems, raft forming systems, swelling and expanding systems.