Abstract

MICROSPHERE: TYPES OF MICROSPHERE, METHOD OF PREPARATION AND APPLICATION ON BRIEF REVIEW

Saurabh, Nisha Devi, Tarun Sharma* and Dr. R. B. Sharma

Abstract

Microspheres are small spherical particles, with diameters range 1 μm to 1000 μm. They are spherical free flowing particles with size less than 200 μm and consisting of proteins or synthetic polymers which are biodegradable in nature microsphere is basically a mixture of drug, dispersed in a polymer form with release occurs by 1st order process. Microspheres are two types; microcapsules and micromatrices in case Microcapsules are those in which entrapped substance is distinctly surrounded by distinct capsule wall. And micromatrices in which entrapped substance is dispersed throughout the matrix. They are made from polymeric waxy or other protective materials such as natural, semi synthetic and synthetic polymers. The present review highlights various types of microspheres, different methods of preparation, its applications and also various parameters to evaluate their efficiency. Microspheres are various types like Bioadhesive microspheres, Magnetic microspheres, Floating microspheres, Radioactive microspheres, Polymeric microspheres, Biodegradable polymeric microspheres, Synthetic polymeric microspheres and are prepared by methods like Emulsion solvent evaporation method, Emulsion cross linking method, Ionic gelation method, Solvent Evaporation, Single emulsion technique, Double emulsion method, Phase separation coacervation technique, Spray drying and spray congealing, Solvent extraction. Microspheres have wide range of applications because of controlled and sustained release.

Keywords: Microsphere, Types Of Microsphere, Method of preparation And Application.