Abstract

FLOATING DRUG DELIVERY SYSTEM: A CRITICAL REVIEW

Jaswinder Singh*, Satvinder Kaur and Jasbir Singh

Abstract

The purpose of writing this review on floating drug delivery systems (FDDS) is to compile the recent literature with special focus on the approaches to achieve gastric retention. Floating Drug delivery systems offers numerous advantages specially the drugs having narrow absorption window in GIT, primary absorption in the stomach, stability problem in the intestine, poor solubility at alkaline pH, local activity in stomach, and property to degrade in colon. In recent years scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently being utilized in the prolongation of the GRT, including floating drug delivery systems, swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices.The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, FDDS types, advantages, disadvantages, evaluation and applications are also reviewed in this article.

Keywords: Gastric retention, floating drug delivery systems, Effervescence and Buoyancy.